State of Utah Center of Excellence for Biomedical Microfluidics
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| Work on microscale electrical field flow fractionation has been ongoing for several years as a part of the center, and served as the initial technology for development of the Center. Microscale ElFFF has been shown to have significant capabilities and is useful for separating nanoparticles of any type including viruses, proteins, DNA, cells, and other materials. Note that the Center is organizing the 13th International Symposium on Field- and Flow- based Separations. Students: Himanshu Sant A number of papers have been published in this area and include: Patent No.
6,136,171, Micromachined Electrical Field- Flow Fractionation System Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Geometric Scaling Effects in Electrical Field- Flow Fractionation. 2. Experimental Verification," Analytical Chemistry, Vol. 74, No. 5, pp. 1024-1030, March 1, 2002. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Geometric Scaling Effects in Electrical Field- Flow Fractionation. 1. Theoretical Analysis," Analytical Chemistry, Vol. 73, No. 10, pp.2345-2352, May 15, 2001. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "A Micromachined Electrical Field- Flow Fractionation System," IEEE Tran. on Biomedical Engineering, Vol. 45, No. 12, pp. 1459-1469, December 1998. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Blood and Protein Separations Using a Micromachined Electrical Field- Flow Fractionation System," in Proc. of MicroTAS 2000, Enschede, Netherlands, May 14-18, 2000, pp. 399-402. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Scaling Effects in a Micromachined Electrical Field - Flow Fractionation System," in Proc. of 1999 First Joint BMES/EMBS Conference, Atlanta, GA, October 13-16, 1999, p. 842. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Characterization of a Micromachined Electrical Field- Flow Fractionation System," in Proc. of the Solid-State Sensor and Actuator Workshop, Hilton Head, SC, June 8-11, pp. 342-345, 1998. Bruce K. Gale, A. Bruno Frazier, and Karin D. Caldwell, "A Micromachined Electrical Field- Flow Fractionation System," in Proc. 10th IEEE International Workshop on Micro Electro Mechanical Systems (MEMS '97), Nagoya, Japan, Jan. 26-30, pp. 317-322, 1997. Himanshu J. Sant and Bruce K. Gale, “Improved Scaling Models for Electrical and General Field Flow Fractionation Systems,” in Proc. 9th International Symposium on Field- Flow Fractionation, Boulder, CO, June 26-29, 2001. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Blood and Protein Separations Using a Micromachined Electrical Field- Flow Fractionation System," in Proc. of the Eighteenth Annual Houston Conference on Biomedical Engineering Research, Houston, TX, Feb 10-11, 2000. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Scaling Effects in a Micromachined Electrical Field Flow Fractionation System," in Proc. 8th International Symposium on Field- Flow Fractionation, Paris, France, Sep. 6-8, 1999. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Characterization of a Micromachined Electrical Field- Flow Fractionation System," in Proc. 7th International Symposium on Field-flow Fractionation, Salt Lake City, UT, Feb. 8-11, 1998. Bruce K. Gale, Dissertation, Scaling Effects in a Microfabricated Electrical Field Flow Fractionation System with Integrated Detector, September 1999. |
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