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Patents

Patent No. 6,136,171, Micromachined Electrical Field- Flow Fractionation System
Inventors: Bruce K. Gale, A. Bruno Frazier, and Karin D. Caldwell

Published Journal Papers:

  1. Sriram Natarajan, Andrew Hatch, David Myszka, and Bruce Gale, “The Effect of Process Conditions on Protein Deposition using a Continuous Flow Microspotter,” Anal. Chem., submitted.

  2. Niel Crews, Carl Wittwer, Robert Palais, and Bruce Gale, “Product Differentiation During Continuous-Flow Thermal Gradient PCR,” Lab. Chip, accepted.

  3. James Stephenson, Cynthia Furse, Bruce Gale, “Portable 100MHz Permanent Magnet NMR Spectrometer, ” IEEE Trans. On Mag. Devices, accepted.

  4. Ryan Sincic, David A. Chang-yen, Louis Barrows, Bruce K. Gale, “Parallel Determination of Phenotypic Cytotoxicity with a Micropattern of Mutant Cell Lines,” PNAS, submitted.

  5. Niel Crews, Carl Wittwer, and Bruce Gale, “Thermal Gradient PCR in a Continuous-Flow Microchip,” Biomed. Microdevices, Vol. 10, No. 2, 2008.

  6. Sriram Natarajan, David Chang-Yen, and Bruce Gale, “Large-area, high-aspect-ratio SU-8 molds for fabrication of PDMS microfluidic devices,” J. Micromech. Microeng. Vol. 18  045021, 2008.

  7. Jenny Greer, Scott O. Sundberg, Carl T. Wittwer, and Bruce K. Gale, “Comparison of glass etching to xurography prototyping of microfluidic channels for DNA melting analysis,” J. Micromech. Microeng., Vol. 17, pp. 2407-2413, 2007.

  8. Sriram Natarajan, Phini S. Katsamba, Adam Miles, Josh Eckman, Giuseppe A. Papalia, Rebecca L. Rich, Bruce Gale, David G. Myszka, “Continuous-flow microfluidic printing of proteins for array-based applications including surface plasmon resonance imaging,” Anal. Biochem. Vol. 373, pp. 141-146, 2008.

  9. F. Zhang, R.J. Gates, V. S. Smentkowski, S. Natarajan, B. K. Gale, R.K. Watt, M.C. Asplund, M.R. Linford, "Direct Adsorption and Detection of Proteins, Including Ferritin, onto Microlens Array Patterned Bioarrays." J. Am. Chem. Soc.; Vol. 129(30); pp. 9252-9253, 2007.

  10. Scott O. Sundberg, Jenny Greer, Robert J. Pryor, Oluwole Elenitoba-Johnson, Carl T. Wittwer, and Bruce K. Gale, "Solution-phase DNA mutation scanning and SNP genotyping by nanoliter melting analysis," Biomedical Microdevices, Vol. 9, pp. 159-166, April 2007.

  11. David A. Chang-Yen, Aju Badardeen and Bruce. K. Gale, "Spin-Assembled Nanofilms for Gaseous Oxygen Sensing," Sensors and Actuators B: Chemical, Vol. 120, p 426-433, Jan 10, 2007.

  12. David A. Chang-Yen, and Bruce. K. Gale, "Design and Fabrication of a Practical, Multianalyte-Capable Optical Biosensor," Journal of Microlithography, Microfabrication, and Microsystems, Vol. 5, pp. 1-8, 2006.

  13. Mark A. Eddings and Bruce K. Gale, “A PDMS-based Diffusion Pump For On-Chip Fluid Handling In Microfluidic Devices,” J. Micromech. Microeng., Vol. 16, pp. 2396-2402, 2006.

  14. Himanshu J. Sant, Jung Woo Kim, and Bruce K. Gale, “Reduction of End Effect-Induced Zone Broadening In Field Flow Fractionation Channels,” Anal. Chem., Vol. 78, pp. 7978-7985, 2006.

  15. David A. Chang-yen, David Myszka, and Bruce K. Gale, "A Novel PDMS Microfluidic Spotter for Fabrication of Protein Chips and Microarrays," JMEMS, Vol. 15, pp. 1145-1151, 2006.

  16. Ameya Kantak, Merugu Srinivas and Bruce K. Gale, "Improved Theory of Cyclical Electrical Field Flow Fractionation," Electrophoresis, Vol. 27, pp. 2833-2843, 2006.

  17. Danny Blanchard, Phil Ligrani, Bruce Gale, "Miniature Single-Disk Viscous Pump (Single-DVP), Performance Characterization," Journal of Fluids Engineering, Vol. 128, pp. 602-610, 2006.

  18. Ameya Kantak, Merugu Srinivas, and Bruce K. Gale, "Carrier Ionic Strength Effects in Cyclical Electrical Field Flow Fractionation," Anal. Chem., Vol. 78, pp. 2557-2564, 2006.

  19. Ameya Kantak, Merugu Srinivas, and Bruce K. Gale, "Characterization of a Microscale Cyclical Electrical Field Flow Fractionation System," Lab. Chip., Vol. 6, pp. 645 - 654, 2006.

  20. Nithin Narayanan, Avinash Saldanha, and Bruce K. Gale, "A Microfabricated Electrical SPLITT System," Lab on a Chip, Vol. 6, pp. 105-114, 2006.

  21. Himanshu J. Sant and  Bruce K. Gale , “Improved Models of Geometric Scaling Effects in Field Flow Fractionation,” Journal of Chromatography A, Vol 1104, pp 282-290, 2006.

  22. JungKyu Kim, Karl Voelkerding, and Bruce K. Gale, "Patterning of an nanoporous membrane for multi-sample DNA extraction," Journal of Micromechanics and Microengineering, Vol. 16, pp. 33-39, 2006.

  23. Danny Blanchard, Phil Ligrani, and Bruce Gale, “Performance and Development of a Miniature Rotary Shaft Pump (RSP),” Journal of Fluids Engineering, Vol. 127, pp. 752-760, 2005.

  24. Danny Blanchard, Phil Ligrani, and Bruce Gale, “Single-Disk and Double-Disk Viscous Micropumps,” Sensors and Actuators A: Physical, Vol. 122, No. 1, 29 July 2005, pp. 149-158, 2005.

  25. D. A. Chang-Yen, R. Eich, Member, and B. K. Gale, “A Monolithic PDMS Waveguide System Fabricated Using Soft-Lithography Techniques,” IEEE Journal of Ligthtwave Technology, Vol. 23, No. 6, pp. 2088-2093, June 2005.

  26. Bruce K. Gale and Merugu Srinivas, "Cyclical Electrical Field Flow Fractionation", Electrophoresis, Vol. 26, pp. 1623-1632, 2005.

  27. Andrew M. Christensen, David A. Chang-Yen, and Bruce K. Gale, “Characterization Of Interconnects Used In PDMS Microfluidic Systems,” Journal of Micromechanics and Microengineering, Vol. 15, pp. 928-935, 2005.

  28. Danny Blanchard, Phil Ligrani,  Bruce Gale, and Ian Harvey, “Micro-Structure Mechanical Failure Characterization Using Rotating Couette Flow in a Small Gap,” Journal of Micromechanics and Microengineering, Vol. 15, pp. 792-801, 2005.

  29. David A. Chang-Yen and Bruce K. Gale, "An Integrated Optical Oxygen Sensor Fabricated Using Rapid-Prototyping Techniques," Lab on a Chip, Vol. 3, pp. 297-301, 2003.

  30. Ameya S. Kantak, Bruce K. Gale, Yuri Lvov, Steven A. Jones, “Platelet Function Analyzer: Shear Activation of Platelets in Microchannels,” Biomedical Microdevices, Vol. 5, pp. 207-215, September, 2003.

  31. David A. Chang-yen, Yuri Lvov, Michael McShane, and Bruce K. Gale, "Electrostatic Self-Assembly Of A Ruthenium-Based Oxygen Sensitive Dye Using Polyion-Dye Interpolyelectrolyte Formation", Sensors and Actuators, B: Chemical, Vol. 87, No. 2, pp. 346-355, December 10, 2002.

  32. Bruce K. Gale, “BioMEMS Education at Louisiana Tech University,” Biomedical Microdevices, Vol. 4, pp. 223-230, July, 2002.

  33. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Geometric Scaling Effects in Electrical Field- Flow Fractionation. 2. Experimental Verification," Analytical Chemistry, Vol. 74, No. 5, pp. 1024-1030, March 1, 2002.

  34. Thayne Edwards, Bruce K. Gale, and A.Bruno Frazier, “A Microfabricated Thermal Field Flow Fractionation System”, Anal. Chem., Vol. 74, No 6, pp. 1211-1216, March 15, 2002.

  35. Thayne Edwards, Bruce K. Gale, and A.Bruno Frazier, “Micro Scale Sample Preparation Systems for Biological Analysis”, Journal of Biomedical MicroDevices, Vol. 3, No. 3, pp. 211-218, 2001.

  36. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Geometric Scaling Effects in Electrical Field- Flow Fractionation. 1. Theoretical Analysis," Analytical Chemistry, Vol. 73, No. 10, pp.2345-2352, May 15, 2001.

  37. A. Bruno Frazier, Karin D. Caldwell, Bruce K. Gale, and Ian Papautsky, "Integrated micromachined components for biological analysis systems," Journal of Micromechatronics, Vol. 1, No. 1, pp. 67-84, 2000.

  38. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "A Micromachined Electrical Field- Flow Fractionation System," IEEE Tran. on Biomedical Engineering, Vol. 45, No. 12, pp. 1459-1469, December 1998.

Book Chapters:

  1. Himanshu Sant and Bruce K. Gale, “Microscale Field Flow Fractionation: Theory and Practice,” in Microfluidic Technologies for Miniaturized Analysis Systems, Steffen Hardt Friedhelm Schönfeld, eds. Springer-Verlag, Berlin, Germany, pp. 471-522, 2007.

  2. Bruce K. Gale, Mark A. Eddings, Scott O. Sundberg, Andrew Hatch, JungKyu Kim, and Tammy Ho. “ Fabrication and packaging: Low-cost MEMS technologies,” in Comprehensive Microsystems, 1st Ed. Yogesh B. Gianchandani, Osamu Tabata, Hans Zappe, eds. Elsevier Amsterdam, Vol. 1, pp. 341-378, 2008.

Invited Papers/Talks:

  1. Bruce K. Gale, “Better Microarrays using Continuous Flow Deposition,” at the GOT Summit: Microarrays in Medicine, Boston, MA, April 12-13, 2007.

  2. Bruce K. Gale, “A decade of progress in microscale FFF,” in Proc. SPIE Microfluidics, BioMEMS, and Medical Microsystems V, San Jose, CA, January 22-27, 2007.

  3. Bruce K. Gale, “Practical Biomedical Microfluidics,” MEMS Technology and Biomedical Applications Gordon Research Conference, New London, CT, June 25-30, 2006.

  4. Bruce K. Gale, David A. Chang-yen, JungKyu Kim, Ameya S. Kantak, Himanshu Sant, and Merugu Srinvas, "A Microfluidic Toolbox for Biomedical and Diagnostic Applications," in Proc. of AICHE 2005, Cincinnati, OH, October 31 - November 3, 2005.

  5. Bruce K. Gale, "Nanoscale Field Flow Fractionation," in Proc. 226th ACS National Meeting, Anaheim, CA, March 27-April 1, 2004.

  6. Bruce K. Gale, "Novel Techniques and Instruments for Field Flow Fractionation of Biological Materials ," in Proc. 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003.

  7. Bruce K. Gale, David Chang-yen, Yuri Lvov, and Michael J. McShane, “Novel Optically-based Oxygen Sensor Fabricated Using a Combination of Microfabrication and Nanotechnology Techniques”, in Proc. Second Annual BioMEMS and Biomedical Nanotechnology World 2001 conference, Columbus, OH, September 22-25, 2001.

  8. Bruce K Gale, Himanshu J Sant, Avinash Saldanha, Meregu Srinivas, Mahesh Thoppil, “Microfabricated Field Flow Fractionation Systems,” in Proc. of the Second Annual Louisiana Microsystems and Materials Conference, Baton Rouge, LA, August 20-22, 2001.

  9. Mengyan Li, John D. Glawe, Heather Green, David K. Mills, Michael J. McShane, Bruce K. Gale. “Microfabricated Substrates for Tissue Engineering,” in Proc. of the Nineteenth Annual Houston Conference on Biomedical Engineering Research, Houston, TX, February 8-9, 2001.

  10. Bruce K. Gale, “Scaling Effects in Microchromatography Systems”, at Regional ACS Conference, New Orleans, LA, December 6-8, 2000.

  11. Bruce K. Gale, Ronald S. Besser, Ian Papautsky, John D. Brazzle, A. Bruno Frazier, “Packaging for Biomedical Analysis Systems,” at the Advanced Technology Workshop (ATW) for MEMS and Microsystem Packaging and Integration, Orlando, FL, November 10-12, 2000.

  12. A. Bruno Frazier, Thayne L. Edwards, and Bruce K. Gale, "Micro Scale Purification Systems for Biological Sample Preparation", in Proc. of 198th Meeting of the Electrochemical Society: Microfabricated Systems and MEMS V, Phoenix, AZ, October 22-27, 2000.

  13. Charles J. Robinson, Stan A. Napper, Bruce K. Gale, Michael J. McShane, "Rehabilitative Biomicrosystems", in Proc.1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Lyon, France, October 12-14, 2000, pp. 547-551.

  14. Bruce K. Gale, Karin Caldwell, and A. Bruno Frazier, “Blood and Protein Separations Using a Micromachined Electrical Field-flow Fractionation System,” in Proc. of the First Annual Louisiana Microsystems Conference, Ruston, LA, April 5, 2000.

  15. A. Bruno Frazier, John Brazzle, Bruce Gale, and Ian Papautsky, "Miniaturized Devices for Bio/Chemical Sample Preparation," in Proc. International Device Research Symposium, Charlottesville, VA, Dec. 1-2, 1999.

  16. A. Bruno Frazier, Ian Papautsky, Thayne Edwards, and Bruce Gale, “Integrated Sample Preparation Systems for Miniaturized Biochemical Analysis,” in Proc. International Symposium on Mechatronics and Human Science (MHS ’99), Nagoya, Japan, Nov. 23-26, 1999.

  17. A. Bruno Frazier, John D. Brazzle, Bruce K. Gale, and Ian Papautsky, "Packaging for Microfluidic Systems," in Proc. of Interpack '99, Lahaina, Hawaii, June 13-18, 1999.

  18. A. Bruno Frazier, Bruce K. Gale, and Ian Papautsky, " Micromachined metallic pipettes and bioanalysis systems," in Proc. International Symposium on Mechatronics and Human Science (MHS '97), Nagoya, Japan, Oct. 5-8, pp. 5-12, 1997.

Reviewed Conference Papers:

  1. Kathryn A. Smith, Bruce K. Gale, John C. Conboy, “Micropatterned Fluid Lipid Bilayers Created Using A Continuous Flow Microspotter For Multi-Analyte Assays,” in Proc. of AICHE 2007, Salt Lake City, Utah, November 3-9, 2007, pp. 576d.

  2. Jianping Liu, Mark A. Eddings, Bruce K. Gale, and Jennifer Shumaker-Parry, “A Three-Dimensional Microfluidic System Integrated With Surface Plasmon Resonance Microscopy For Immunoassays,” in Proc. of AICHE 2007, Salt Lake City, Utah, November 3-9, 2007, pp. 523f.

  3. Rajesh Surapaneni, Jungkyu Kim, Bruce Gale, "Microfluidic gDNA Quantification by Flow Rate Analysis", in Proc. of AIChE, 2007 Annual Meeting, Salt Lake City, UT, November 3-9, 2007, pp. 521.

  4. Jungkyu Kim and Bruce K. Gale, “Evaluation of a Microfluidic DNA Extraction System Using A Nanoporous Aluminum Oxide Membrane,” in Proc. of MicroTAS 2007, Paris, France, Oct. 7-11, 2007, pp. 643-645.

  5. Himanshu J. Sant, Tammy Ho, and Bruce K. Gale, “A Microfluidic Switchboard,” in Proc. of MicroTAS 2007, Paris, France, Oct. 7-11, 2007, pp. 1131-1133.

  6. Niel Crews, Carl Wittwer, and Bruce Gale, "Thermal Gradient PCR in a Continuous-Flow Microchip," n Proc. Of SPIE: Microfluidics, BioMEMS, and Medical Microsystems V, San Jose, CA, January 23-28, Vol. 6465, pp. 646504 (1-11), 2007.

  7. Niel Crews, Carl Wittwer, Luming Zhou, and Bruce Gale, “Rapid Prototyping of a Continuous-Flow PCR Microchip,” AICHE 2006, San Francisco, CA, Nov. 12-17, 2006.

  8. Scott O. Sundberg, Jenny Greer, Carl T. Wittwer, Robert J. Pryor, Oluwole Elenitoba-Johnson, and Bruce K. Gale, “Homogeneous DNA Melting Analysis For Mutation Scanning Using Nanoliter Volumes,” in Proc. of MicroTAS 2006, Tokyo, Japan, Nov. 5-9, 2006, pp. 1441-1443.

  9. Jungkyu Kim and Bruce K. Gale, “Geometric Optimization Of A Thin Film Ito Heater To Generate A Uniform Temperature Distribution,” in Proc. of MicroTAS 2006, Tokyo, Japan, Nov. 5-9, 2006, pp. 293-295.

  10. Mark A. Eddings and Bruce K. Gale, “A PDMS Diffusion Pump For On-Chip Fluid Handling In Microfluidic Devices,” in Proc. of MicroTAS 2006, Tokyo, Japan, Nov. 5-9, 2006, pp. 44-46.

  11. JungKyu Kim and Bruce K. Gale, "Microfluidic DNA Extraction Using a Patterned Aluminum Oxide Membrane," in Proc. Of SPIE: Microfluidics, BioMEMS, and Medical Microsystems IV, San Jose, CA, January 23-28, 2006.

  12. D. A. Chang-Yen, and B. K. Gale, "Design and Fabrication of a Multianalyte-Capable Optical Biosensor Using a Multiphysics Approach," in Proc. Of IEEE-MMB 2005, Oahu, Hawaii, May 12-15, 2005.

  13. D. A. Chang-Yen, and B. K. Gale, "A PDMS Microfluidic Spotter for Fabrication of Lipid Microarrays," in Proc. Of IEEE-MMB 2005, Oahu, Hawaii, May 12-15, 2005.

  14. Jungkyu Kim, Bruce K. Gale, "Multi-DNA Extraction Chip Based on an Aluminum Oxide Membrane Integrated into a PDMS Microfluidic Structure," in Proc. Of IEEE-MMB 2005, Oahu, Hawaii, May 12-15, 2005, pp. 5-7.

  15. M. Graff, B.K. Gale and A.B. Frazier, Nanoparticle Separations Using Miniaturized Field-Flow Fractionation Systems, to be published in Proc. of 2005 NSTI Nanotechnology Conference and Trade Show, May 8-12, 2005, Anaheim, California, U.S.A., pp. 455-458.

  16. David A. Chang-yen and Bruce K. Gale, “PDMS microfluidic spotter for fabrication of protein chips and micro-arrays,”  in Proc. Of SPIE: Microfluidics, BioMEMS, and Medical Microsystems III, San Jose, CA, January 22-27, 2005

  17. Danny Blanchard, Phil Ligrani, and Bruce Gale, “Single-Disk and Double-Disk Viscous Micropumps,” to Proceedings of IMECE2004, November 13-19, 2004 , Anaheim , California USA .

  18. Danny Blanchard, Phil Ligrani, and Bruce Gale, “Performance and Development of a Miniature Rotary Shaft Pump (RSP),” in Proceedings of IMECE2004, November 13-19, 2004, Anaheim , California USA .

  19. Tim Ameel, Bruce Gale, and Ian Harvey, “A Three-semester Interdisciplinary Educational Program in Microsystems Engineering,” in Proc. Of 2004 ASEE International Conference and Exposition, Salt Lake City , Utah , June 20-24, 2004 .

  20. David A. Chang-yen and Bruce K. Gale, "Integrated optical glucose sensor fabricated using PDMS waveguides on a PDMS substrate," Proc. Of SPIE: Microfluidics, BioMEMS, and Medical Microsystems II, San Jose, CA, Vol. 5345, January 25-27, 2004, pp. 98-107.

  21. Himanshu J. Sant and Bruce K. Gale, "Flexible coupling of a waveguide detector with a microscale field flow fractionation device," Proc. Of SPIE: Microfluidics, BioMEMS, and Medical Microsystems II, San Jose, CA, Vol. 5345, January 25-27, 2004, pp. 250-257.

  22. Himanshu J. Sant, Bruce K. Gale, "An Integrated Optical Detector For Microfabricated Electrical Field Flow Fractionation System," in Proc. of MicroTAS 2003, Squaw Valley, California, October 5-9, 2003.

  23. Ameya S Kantak, Srinivas Merugu, Bruce K Gale, "Microfabricated Cyclical Electrical Field Flow Fractionation," in Proc. of MicroTAS 2003, Squaw Valley, California, October 5-9, 2003.

  24. Srinivas Merugu, Nithin Narayanan and Bruce K. Gale, "High Throughput Separations Using A Microfabricated Serial Electric SPLITT System," in Proc. of MicroTAS 2003, Squaw Valley, California, October 5-9, 2003.

  25. Jung Woo Kim, Himanshu J Sant and Bruce K Gale, "Reduction of Microfluidic End Effects In Micro-Field Flow Fractionation Channels," in Proc. of MicroTAS 2003, Squaw Valley, California, October 5-9, 2003.

  26. David A. Chang-yen and Bruce K. Gale, "An Integrated Optical Biochemical Sensor Fabricated Using Rapid-Prototyping Techniques," in Proc. of SPIE: Microfluidics, BioMEMS, and Medical Microsystems, San Jose, CA, Vol. 4982, January 27-29, 2003, pp. 185-195.

  27. Avinash D Saldanha and Bruce K Gale, "Viral Separations using a Microfabricated Electrical SPLITT System", in Proc. of MicroTAS 2002, Nara, Japan, November 2002.

  28. Ameya Kantak, Bruce Gale, Yuri Lvov, Steven Jones, “Microfluidic Platelet Function Analyzer For Shear-induced Platelet Activation Studies,” in Proc. Of IEEE-MMB 2002, Madison, WI, May 2-4, 2002, pp. 169-173.

  29. Mengyan Li, Hua Ai, David K. Mills, Yuri M. Lvov, Michael J. McShane, Bruce K Gale, “Using Microfabrication and Electrostatic Layer-by-layer (LbL) Self-Assembly Technologies to Improve the Growth and Alignment of Smooth Muscle Cells,” in Proc. of IEEE-MMB 2002, Madison, WI, May 2-4, 2002, pp. 109-114.

  30. David A. Chang-Yen and Bruce K. Gale, “A Novel Integrated Optical Dissolved Oxygen Sensor For Cell Culture And Micro Total Analysis Systems,” in Proc. MEMS 2002, Las Vegas, Nevada, January 20-24, 2002 pp.574-577.

  31. Himanshu J. Sant and Bruce K. Gale, "A Microfabricated Thermal Electric Field Flow Fractionation System," in Proc. of MicroTAS 2001, Monterrey, California, October 21-25, 2001, pp. 563-564.

  32. Mengyan Li, John D. Glawe, Heather Green, David K. Mills, Michael J. McShane, Bruce K. Gale. “Effect of High Aspect Ratio Microstructures on Cell Growth and Attachment," in Proc.1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Lyon, France, October 12-14, 2000, pp. 531-536.

  33. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Blood and Protein Separations Using a Micromachined Electrical Field- Flow Fractionation System," in Proc. of MicroTAS 2000, Enschede, Netherlands, May 14-18, 2000, pp. 399-402.

  34. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Scaling Effects in a Micromachined Electrical Field - Flow Fractionation System," in Proc. of 1999 First Joint BMES/EMBS Conference, Atlanta, GA, October 13-16, 1999, p. 842.

  35. Thayne L. Edwards, Bruce K. Gale, and A. Bruno Frazier, "Miniaturized Thermal Field-Flow Fractionation System" in Proc. of 1999 First Joint BMES/EMBS Conference, Atlanta, GA, October 13-16, 1999, p.848.

  36. Bruce K. Gale and A. Bruno Frazier, "Electrical Impedance Spectroscopy Particle Detector for Use in Microanalysis Systems," in Proc. SPIE Symposium on Micromachining and Microfabrication: Micro Fluidic Devices and Systems, Santa Clara, CA, Sep. 20-21, 1999, 190-201.

  37. Ian Papautsky, Bruce K. Gale, Swomitra Mohanty, Tim A. Ameel, and A. Bruno Frazier, "Effects of rectangular microchannel aspect ratio on laminar friction constant," in Proc. SPIE Symposium on Micromachining and Microfabrication: MicroFluidic Devices and Systems, Santa Clara, CA, Sep. 20-21, 1999, pp. 147-158.

  38. Thayne L. Edwards, Bruce K. Gale, and A. Bruno Frazier, "A Micromachined Thermal Field- Flow Fractionation System, in Proc. of Transducers '99, 1999 International Conference on Solid-State Sensors and Actuators, Sendai, Japan, June 7-11, 1999.

  39. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Electrical Conductivity Particle Detector for Use in Biological and Chemical Micro-analysis Systems," in Proc. SPIE Symposium on Micromachining and Microfabrication: Micro Fluidic Devices and Systems, Santa Clara, CA, Sep. 21-24, pp. 230-242, 1998.

  40. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Characterization of a Micromachined Electrical Field- Flow Fractionation System," in Proc. of the Solid-State Sensor and Actuator Workshop, Hilton Head, SC, June 8-11, pp. 342-345, 1998.

  41. Bruce K. Gale, A. Bruno Frazier, and Karin D. Caldwell, "A Micromachined Electrical Field- Flow Fractionation System," in Proc. 10th IEEE International Workshop on Micro Electro Mechanical Systems (MEMS '97), Nagoya, Japan, Jan. 26-30, pp. 317-322, 1997. (37.7% acceptance rate)

Conference Papers:

  1. Jianping Liu, Mark A. Eddings, Bruce K. Gale, and Jennifer Shumaker-Parry, “SPR microscopy combined with a 3-D microfluidic system for high-throughput bioanalysis,” ACS National Meeting 2007, Boston, Massachusetts, August 19-23, 2007.

  2. Scott O. Sundberg, Carl T. Wittwer, Bruce K Gale, “Microchip Warfarin Metabolism Genotyping Using DNA Melting Analysis,” Third Annual Mountain West Biomedical Engineering Conference, Park City, UT, Sept 21-22. 2007.

  3. Mark A Eddings, Jianping Liu, Jennifer Shumaker-Parry, Bruce K Gale, “High-throughput in situ Biomolecule Analysis Integrating a 3-D Microfluidic Flow Cell Array and SPR Microscopy,” Third Annual Mountain West Biomedical Engineering Conference, Park City, UT, Sept 21-22. 2007.

  4. Mark A. Eddings, Jianping Liu, Jennifer Shumaker-Parry, and Bruce K. Gale, “High-throughput in situ biomolecule analysis integrating a 3-D Microfluidic Flow Cell Array and SPR Microscopy,” presented at Gordon Research Conference on Physics and Chemistry of Microfluidics, Waterville Valley, New Hampshire, June 2007.

  5. Srinivas Merugu, and Bruce K. Gale, “Combining Normal and Cyclical Electrical Field Flow Fractionation,” in Proc. of 13th International Symposium on Field-and Flow-based Separation, Salt Lake City, UT, June 27-30, 2007, pp. L33.

  6. Himanshu J. Sant, Srinivas Merugu, and Bruce K. Gale, “Numerical Simulations of Transport Processes in Electrical Field-Flow Fractionation Systems,” in Proc. of 13th International Symposium on Field-and Flow-based Separation, Salt Lake City, UT, June 27-30, 2007, pp. P31.

  7. Himanshu J.Sant and Bruce K. Gale, “Improvements in Microscale Thermal-Field Flow Fractionation Instrumentation,” in Proc. of 13th International Symposium on Field-and Flow-based Separation, Salt Lake City, UT, June 27-30, 2007, pp. P41.

  8. Sriram Natarajan, Bruce K. Gale, and David G. Myszka, “Continuous Flow Enhancement of Microarray Spots for Flexchip Analysis,” in Proc. of Developments in Protein Interaction Analysis 2007, May 6-9, 2007, Phoenix, AZ.

  9. Mark A. Eddings and Bruce K. Gale, “A PDMS Diffusion Pump For On-Chip Fluid Handling In Microfluidic Devices,” in Proc. Of The  Second Annual Mountain West Biomedical Engineering Conference, Snowbird, UT, Sept 15-17, 2006.

  10. Scott O. Sundberg, Jenny Greer, Carl T. Wittwer, Robert J. Pryor, Oluwole Elenitoba-Johnson, and Bruce K. Gale, “Homogeneous DNA Melting Analysis For Mutation Scanning Using Nanoliter Volumes,” in Proc. Of The  Second Annual Mountain West Biomedical Engineering Conference, Snowbird, UT, Sept 15-17, 2006.

  11. Jungkyu Kim and Bruce K. Gale, “Geometric Optimization Of A Thin Film Ito Heater To Generate A Uniform Temperature Distribution,” in Proc. Of The  Second Annual Mountain West Biomedical Engineering Conference, Snowbird, UT, Sept 15-17, 2006.

  12. Jungkyu Kim, Karl V. Voelkerding, Bruce K. Gale “Microfluidic DNA extraction array with patterned AIOx membrane,” in Proc. Of The 1st Annual Mountain West Biomedical Engineering Conference, Snowbird, UT, September 16-17, 2005.

  13. H.J. Sant and B.K. Gale, “Field programming in microscale electrical field flow fractionation,” in Proc. Of The 1st Annual Mountain West Biomedical Engineering Conference Snowbird, UT, September 16-17, 2005.

  14. Scott O. Sundberg, Carl T. Wittwer, Bruce K. Gale, “DNA Melting Analysis on a Nano-Volume Scale,” in Proc. Of The 1st Annual Mountain West Biomedical Engineering Conference, Snowbird, UT, September 16-17, 2005.

  15. Phini Katsamba, Rebecca Rich, Michelle Cannon, Jerry Jenkins, Prabhakar Pandian, Bruce Gale, Shankar Sundaram & David Myszka, "Extracting Kinetics from the Array-Based FLEXchip SPR Biosensor," in Proc. of Developments in Protein Interaction Analysis Conference 2005, Philadelphia, PA, August 28-31, 2005.

  16. Ameya Kantak, Srinivas Merugu, and Bruce K. Gale, "Improved Theory of CyElFFF and Characterization of m-CyElFFF," in Proc. Of the 12th International Symposium on Field Flow Fractionation, Brno, Czech Republic, August, 28-30, 2005.

  17. Himanshu Sant and Bruce K. Gale, "An Integrated polymer waveguide based optical flowcell for microscale field flow fractionation systems," in Proc. Of the 12th International Symposium on Field Flow Fractionation, Brno, Czech Republic, August, 28-30, 2005.

  18. Himanshu Sant and Bruce K. Gale, "Field programming in microscale electrical field flow fractionation," in Proc. Of the 12th International Symposium on Field Flow Fractionation, Brno, Czech Republic, August, 28-30, 2005.

  19. D. A Chang-Yen, D. Myszka and B. K. Gale, “A PDMS Microfluidic Spotter for Fabrication of Protein Chips and Microarrays,” in Proc. Of LabAutomation 2005, San Jose, CA January 30 - February 3, 2005

  20. Harvey, Ian R.; Miller, Mark S.; Blair, Steve; Ameel, Tim; Gale, Bruce K.; Ring, Terry, "Building academic, research, and commercialization programs in micro and nano science and engineering at the University of Utah," Biennial University/Government/Industry Microelectronics Symposium - Proceedings, 2003, p 33-35.

  21. Ameya Kantak and Bruce K. Gale, "Microscale Cyclical Electrical Field Flow Fractionation," in Proc. Of the 11th International Symposium on Field Flow Fractionation, Cleveland, OH, October 7-10, 2003.

  22. Himanshu Sant and Bruce K. Gale, "Optical Detectors for Miniaturized FFF Systems," in Proc. Of the 11th International Symposium on Field Flow Fractionation, Cleveland, OH, October 7-10, 2003.

  23. Srinivas Merugu, Nithin Narayanan, and Bruce K. Gale, "Microscale Serial SPLITT Systems," in Proc. Of the 11th International Symposium on Field Flow Fractionation, Cleveland, OH, October 7-10, 2003.

  24. Siddharth Chakravarthy and Bruce K. Gale, "PolyPIPosome Characterization using a Combination of Normal and Cyclical Electrical Field Flow Fractionation," in Proc. Of the 11th International Symposium on Field Flow Fractionation, Cleveland, OH, October 7-10, 2003.

  25. Meregu Srinivas and Bruce K. Gale, "Cyclical Electrical Field Flow Fractionation," in Proc. Of the 10th International Symposium on Field Flow Fractionation, Amsterdam, Netherlands, July 2-5, 2002.

  26. Himanshu J. Sant and Bruce K. Gale, "A Microfabricated Thermal Electric Field Flow Fractionation System," in Proc. Of the 10th International Symposium on Field Flow Fractionation, Amsterdam, Netherlands, July 2-5, 2002.

  27. Avinash Saldanha and Bruce K. Gale, "Microfabricated Electrical SPLITT System," in Proc. of the 10th International Symposium on Field Flow Fractionation, Amsterdam, Netherlands, July 2-5, 2002.

  28. Sreenivas Rao, Himanshu Sant, and Bruce K. Gale, "Minimization of End Effects in Field Flow Fractionation," in Proc. Of the 10th International Symposium on Field Flow Fractionation, Amsterdam, Netherlands, July 2-5, 2002.

  29. Charles J Robinson, K Briski, B Choi, PD Coppola, T-H Cui, A Dunn, T Ehsan, Bruce K Gale, W Green, AM Hollister, A Jawahar, HF Ji, S Jones, Y Lvov, M McShane, D Mills, J Patterson, S Patton, H Price, S Roerig, M Sahin, R Schubert, W Simms, K Varahramyan, "The Newlane Consortium (Neural Engineering With Louisiana North Excellence) Building Newlanes To Record And Restore Neural Function," in Proc. of Third Rehabilitation Research and Development Conference: Rehabilitation Research for the Twenty-First Century: The New Challenges, Arlington, VA, February 10-12, 2002.

  30. Mengyan Li, Hua Ai, David K. Mills, Yuri M. Lvov, Bruce K. Gale, "Increasing the Alignment of Smooth Muscle Cells by 100 mm Channels with Micro- and Nano- Technology," in Proc. of IBE 2002 International Meeting: Interfacing Biology and Engineering, Baton Rouge, LA, January 18-20, 2002

  31. John Glawe, David Mills, and Bruce K. Gale, "Analysis of Cell Organization in a Smooth Muscle Culture Grown On High Aspect Ratio Microstructures," in Proc. of IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11), San Francisco, CA, October 28 - November 2, 2001.

  32. Ameya Kantak, Himanshu Sant, Bruce K. Gale, David K. Mills, Yuri Lvov, and Steve Jones, "A Microfabricated Platelet Analyzer," in Proc. Smalltalk 2001, San Diego, CA, August 27-31, 2001.

  33. Himanshu J. Sant and Bruce K. Gale, “Improved Scaling Models for Electrical and General Field Flow Fractionation Systems,” in Proc. 9th International Symposium on Field- Flow Fractionation, Boulder, CO, June 26-29, 2001.

  34. Avinash Saldanha and Bruce K. Gale, “A Microfabricated Electrical SPLITT System,” in Proc. 9th International Symposium on Field- Flow Fractionation, Boulder, CO, June 26-29, 2001.

  35. Bruce K. Gale and Mahesh Thoppil, “A Microfabricated Cyclical Electrical Field Flow Fractionation System,” in Proc. 9th International Symposium on Field- Flow Fractionation, Boulder, CO, June 26-29, 2001.

  36. Bruce K. Gale, “Microfabricated FFF and SPLITT Systems,” in Proc. Tex MEMS III, Dallas, TX, June 7, 2001.

  37. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Blood and Protein Separations Using a Micromachined Electrical Field- Flow Fractionation System," in Proc. of the Eighteenth Annual Houston Conference on Biomedical Engineering Research, Houston, TX, Feb 10-11, 2000.

  38. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Scaling Effects in a Micromachined Electrical Field Flow Fractionation System," in Proc. 8th International Symposium on Field- Flow Fractionation, Paris, France, Sep. 6-8, 1999.

  39. Bruce K. Gale, Karin D. Caldwell, and A. Bruno Frazier, "Characterization of a Micromachined Electrical Field- Flow Fractionation System," in Proc. 7th International Symposium on Field-flow Fractionation, Salt Lake City, UT, Feb. 8-11, 1998.

  40. A. Bruno Frazier, Karin D. Caldwell, Tim Ameel, Bruce Gale, and Ian Papautsky, "Micro scale fluid analysis systems: applications and engineering issues," in Proc. 7th International Symposium on Field-flow Fractionation, Salt Lake City, UT, Feb. 8-11, 1998.

Invited Workshop Presentations:

  1. Bruce K. Gale, "Active Components for Microfluidic Manipulation," CAMD / CBM2 2005 Summer Workshop, Baton Rouge, Louisiana, July 25-29, 2005.

  2. Bruce K. Gale, Ian Harvey, and Tim Ameel, "MEMS Workshop" sponsored by Korean Government, January 12-16, 2004. Full week course involving lectures and labs for 8 Professors from Korea on MEMS and MEMS education.

  3. Bruce K. Gale and Michael J. McShane, “BioMEMS and Biomedical Optics,” Shortcourse Sponsored by Government of Taiwan (ROC), March 6-8, 2001 (Full three days of presentations: Over 100 paid attendees).

  4. Bruce K. Gale, “Advanced Bio-MEMS Techniques and Research Applications” BioMEMS workshop at Chicago 2000, the World Congress on Medical Physics and Biomedical Engineering, Chicago, IL, July 22, 2000.

  5. Bruce K. Gale, “Introduction to BioMEMS,” Microfabrication Short Course held with the First Annual Louisiana Microsystems Conference, Ruston, LA, April 4, 2000.

  6. Bruce K. Gale, Laboratory Instruction in Microfabrication, MEMS Bootcamp, Univ. of Utah, May 1999.

Supervised Theses

Bruce K. Gale, Scaling Effects in a Microfabricated Electrical Field Flow Fractionation System with Integrated Detector, September 1999.

David Chang-yen, Electrostatic Self-assembly of a Ruthenium-based Oxygen Sensitive Dye Using Polyion-dye Interpolyelectrolyte Formation, August 2002

Meregu Srinivas, Cyclical Electrical Field Flow Fractionation, June 2002

Himanshu Sant, Improved Models for Electrical Field Flow Fractionation

Mengyan Li

Krishnan Padmanabhan

Avinash Saldanha, A Microfabricated Electrical SPLITT System, February 2002

Ameya Kantak

John Glawe, ALIGNMENT OF RAT AORTIC SMOOTH MUSCLE CELLS BY HIGH ASPECT RATIO MICROFABRICATED ELASTOMERIC MICROCHANNEL CELL CULTURE SCAFFOLDS, November 2003

Nithin Narayanan, A microfabricated SPLITT System, March 2004

 
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